Beilstein J. Org. Chem.2016,12, 571–588, doi:10.3762/bjoc.12.56
ketosynthases which catalyze Claisen-like condensation reactions, will be presented.
Keywords: α-pyrones; biological activity; interconnectingketosynthases; natural product; polyketides; Introduction
α-Pyrones (1, also 2-pyrones) represent a moiety widespread in nature (Figure 1). The motif of a six-membered
isolation studies and lead discovery. Now, new insights into the biosynthesis of these molecules through chain interconnectingketosynthases were obtained. This opens up the possibility to use these enzymes as tools; both, in bio- as well as in semi-synthetic approaches. The potential of these enzymes in
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Graphical Abstract
Figure 1:
Selected monocyclic and monobenzo α-pyrone structures.